Introduction: Material characteristics of pharmaceutical intermediatesPharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. This chemical product does not require a drug production license …
Pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. This chemical product does not require a drug production license and can be produced in ordinary chemical plants, as long as it reaches a certain level. , Can be used for the synthesis of medicines.
The double cone rotary vacuum dryer is a drying equipment integrating mixing and vacuum drying. The process of vacuum drying is to put the material to be dried in a sealed cylinder, and use the vacuum system to draw a vacuum while heating the material to be dried continuously, so that the water inside the material diffuses to the surface through the pressure difference or the concentration difference, and the water molecules (or other Non-condensable gas) obtains sufficient kinetic energy on the surface of the material, and after overcoming the mutual attraction between molecules, it diffuses into the low-pressure space of the vacuum chamber and is pumped away by the vacuum pump to complete the separation from the solid. Therefore, the double cone rotary vacuum dryer has the following characteristics:
(1) During the vacuum drying process, the pressure in the cylinder is always lower than the atmospheric pressure, the number of gas molecules is small, the density is low, and the oxygen content is low. Therefore, it can dry easily oxidized drugs and reduce the chance of material contamination.
(2) Because the temperature of moisture is proportional to the vapor pressure during the vaporization process, the moisture in the material can be vaporized at low temperature during vacuum drying to achieve low-temperature drying, which is especially suitable for the production of heat-sensitive materials.
(3) Vacuum drying can eliminate the surface hardening phenomenon that is easily caused by normal pressure hot air drying. This is because the pressure difference between the inside and the surface of the vacuum drying material is large. Under the pressure gradient, the water will quickly move to the surface, and the surface will not appear. hardening.
(4) Due to the small temperature gradient between the inside and outside of the material during vacuum drying, the moisture can move and collect independently due to reverse osmosis, which effectively overcomes the loss of hot air drying.
The theory shows that the equipment also has the following characteristics: (1) Constant heating temperature, increasing vacuum degree, and speeding up; (2) Constant vacuum degree, increasing heating temperature, speeding up speed; (3) Increasing vacuum degree and heating temperature , The rate is greatly accelerated. (4) The heating medium can be hot water or steam (the steam pressure is 0.40-0.50Mpa); (5) The inner wall of the dryer adopts an arc transition to avoid sanitary dead corners and the condensate flow of the solvent in the layer of the tray after condensation.
The machine is simple to operate and convenient to feed in and out, which greatly reduces the labor intensity of workers. At the same time, it also reduces the environmental pollution of materials during the drying process, improves product quality, and meets the requirements of the drug management standard "GMP".